Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients.
Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.In mouse and fly models, agonists of the GABAA Ambulatory Accessories receptor were able to rescue specific consequences of the fragile X mutation.Here, we im